Cost-benefit analysis of calcium and vitamin D supplements.
- Weaver CM Department of Nutrition Science, College of Health and Human Sciences, Purdue University, 700 W State Street, West Lafayette, IN, 47907-2059, USA. weavercm@purdue.edu.
- Bischoff-Ferrari HA Department of Geriatric Medicine and Aging Research, University Hospital and University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
- Shanahan CJ Frost & Sullivan, 7550 Interstate 10 Frontage Rd #400, San Antonio, TX, 78229, USA.
- 2019-05-02
Published in:
- Archives of osteoporosis. - 2019
Bone fracture
Calcium
Cost savings
Costs and cost analysis
Osteoporosis
Vitamin D
Adult
Aged
Calcium, Dietary
Cost-Benefit Analysis
Dietary Supplements
Female
Humans
Male
Meta-Analysis as Topic
Middle Aged
Osteoporotic Fractures
Randomized Controlled Trials as Topic
Systematic Reviews as Topic
Vitamin D
English
If all adults with osteoporosis in the European Union (EU) and United States (US) used calcium and vitamin D supplements, it could prevent more than 500,000 fractures/year in the EU and more than 300,000/year in the US and save approximately €5.7 billion and US $3.3 billion annually.
PURPOSE
Evaluate the cost-effectiveness of calcium/vitamin D supplementation for preventing osteoporotic fractures.
METHODS
A cost-benefit analysis tool was used to estimate the net cost savings from reduced fracture-related hospital expenses if adults with osteoporosis in the EU and US used calcium/vitamin D supplements. A 14% relative risk reduction of fracture with calcium/vitamin D supplementation from a recent systematic review and meta-analysis of randomized, controlled trials was used as the basis for the benefit estimate. Other model inputs were informed by epidemiologic, clinical, and cost data (2016-2017) obtained via the medical literature or public databases. Analyses estimated the total number of avoided fractures and associated cost savings with supplement use. Net cost benefit was calculated by subtracting the supplements' market costs from those savings.
RESULTS
The > 30 million persons in the EU and nearly 11 million in US with osteoporosis experience about 3.9 million and 2.3 million fractures/year and have annual hospital costs exceeding €50 billion and $28 billion. If all persons with osteoporosis used calcium and vitamin D supplements, there would be an estimated 544,687 fewer fractures/year in the EU and 323,566 fewer in the US, saving over €6.9 billion and $3.9 billion; the net cost benefit would be €5,710,277,330 and $3,312,236,252, respectively.
CONCLUSIONS
Calcium and vitamin D supplements are highly cost-effective, and expanded use could considerably reduce fractures and related costs. Although these analyses included individuals aged ≥ 50 years, the observed effects are likely driven by benefits observed in those aged ≥ 65 years.
PURPOSE
Evaluate the cost-effectiveness of calcium/vitamin D supplementation for preventing osteoporotic fractures.
METHODS
A cost-benefit analysis tool was used to estimate the net cost savings from reduced fracture-related hospital expenses if adults with osteoporosis in the EU and US used calcium/vitamin D supplements. A 14% relative risk reduction of fracture with calcium/vitamin D supplementation from a recent systematic review and meta-analysis of randomized, controlled trials was used as the basis for the benefit estimate. Other model inputs were informed by epidemiologic, clinical, and cost data (2016-2017) obtained via the medical literature or public databases. Analyses estimated the total number of avoided fractures and associated cost savings with supplement use. Net cost benefit was calculated by subtracting the supplements' market costs from those savings.
RESULTS
The > 30 million persons in the EU and nearly 11 million in US with osteoporosis experience about 3.9 million and 2.3 million fractures/year and have annual hospital costs exceeding €50 billion and $28 billion. If all persons with osteoporosis used calcium and vitamin D supplements, there would be an estimated 544,687 fewer fractures/year in the EU and 323,566 fewer in the US, saving over €6.9 billion and $3.9 billion; the net cost benefit would be €5,710,277,330 and $3,312,236,252, respectively.
CONCLUSIONS
Calcium and vitamin D supplements are highly cost-effective, and expanded use could considerably reduce fractures and related costs. Although these analyses included individuals aged ≥ 50 years, the observed effects are likely driven by benefits observed in those aged ≥ 65 years.
- Language
-
- English
- Open access status
- hybrid
- Identifiers
-
- DOI 10.1007/s11657-019-0589-y
- PMID 31041620
- Persistent URL
- https://fredi.hepvs.ch/global/documents/94590
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