Journal article
Microstructural retinal regeneration after internal limiting membrane flap surgery for repair of large macular holes: a 1-year follow-up study.
- Vieregge M Eye Clinic, Cantonal Hospital Sankt Gallen, Rorschacherstrasse 95, Sankt Gallen, 9007, Switzerland.
- Valmaggia C Eye Clinic, Cantonal Hospital Sankt Gallen, Rorschacherstrasse 95, Sankt Gallen, 9007, Switzerland.
- Scholl HPN Department of Ophthalmology, University Hospital Basel, Basel, Switzerland.
- Guber J Eye Clinic, Cantonal Hospital Sankt Gallen, Rorschacherstrasse 95, Sankt Gallen, 9007, Switzerland. josef_guber@hotmail.com.
- 2018-05-11
Published in:
- International ophthalmology. - 2019
Ellipsoid zone
Free flap
Internal limiting membrane flap
Inverted flap
Macular hole
Aged
Aged, 80 and over
Basement Membrane
Female
Follow-Up Studies
Humans
Male
Middle Aged
Retina
Retinal Perforations
Surgical Flaps
Visual Acuity
Vitrectomy
English
PURPOSE
To evaluate long-term change in functional and structural outcomes after successful repair of large macular holes (MH) with internal limiting membrane (ILM) flap techniques.
METHODS
Eleven consecutive patients were reviewed over a 1-year time period after the successful repair of large MH with ILM flap techniques. SD-optical coherence tomography (SD-OCT) images were taken to assess the anatomical outcome after surgery, while the best-corrected visual acuity (BCVA) was tested using Snellen charts to evaluate the functional outcome. Each patient was evaluated at 1, 6 and 12 months after surgery, respectively.
RESULTS
All cases achieved complete anatomical closure. All patients showed a microstructural regeneration of the retina with a decrease in ellipsoid zone defects over the 1-year follow-up. Functionally, as compared to baseline, all of the patients showed improvements in best-corrected visual acuity of 1-4 lines at the final examination after 12 months post-operatively.
CONCLUSIONS
Long-term results show further improvement in the best-corrected visual acuity as well as further microstructural regeneration of the retina and decrease in ellipsoid zone defects over time. The exact mechanism, which promotes closure of the macular hole and reconstruction of the ellipsoid zone after internal Limiting Membrane autograft surgery, still remains unknown.
To evaluate long-term change in functional and structural outcomes after successful repair of large macular holes (MH) with internal limiting membrane (ILM) flap techniques.
METHODS
Eleven consecutive patients were reviewed over a 1-year time period after the successful repair of large MH with ILM flap techniques. SD-optical coherence tomography (SD-OCT) images were taken to assess the anatomical outcome after surgery, while the best-corrected visual acuity (BCVA) was tested using Snellen charts to evaluate the functional outcome. Each patient was evaluated at 1, 6 and 12 months after surgery, respectively.
RESULTS
All cases achieved complete anatomical closure. All patients showed a microstructural regeneration of the retina with a decrease in ellipsoid zone defects over the 1-year follow-up. Functionally, as compared to baseline, all of the patients showed improvements in best-corrected visual acuity of 1-4 lines at the final examination after 12 months post-operatively.
CONCLUSIONS
Long-term results show further improvement in the best-corrected visual acuity as well as further microstructural regeneration of the retina and decrease in ellipsoid zone defects over time. The exact mechanism, which promotes closure of the macular hole and reconstruction of the ellipsoid zone after internal Limiting Membrane autograft surgery, still remains unknown.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1007/s10792-018-0941-z
- PMID 29744761
- Persistent URL
- https://fredi.hepvs.ch/global/documents/49700
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