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The role of perforin in infections and tumour surveillance.
Journal article

The role of perforin in infections and tumour surveillance.

  • van den Broek MF Institute of Experimental Immunology, Department of Pathology, University of Zürich, Switzerland. maries@pathol.unizh.ch
  • Hengartner H
  • 2001-02-24
Published in:
  • Experimental physiology. - 2000
Animals
Autoimmunity
Bacterial Infections
Immunologic Surveillance
Infections
Killer Cells, Natural
Membrane Glycoproteins
Neoplasms
Perforin
Pore Forming Cytotoxic Proteins
T-Lymphocytes, Cytotoxic
Virus Diseases
English Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells are able to lyse suitable target cells. CTLs recognize a specific peptide epitope presented by major histocompatibility complex (MHC) class I molecules on the target cells, whereas NK cells lyse targets that express no or low MHC class I molecules. Using perforin-deficient mice, we provide evidence that both NK cells and CTLs exclusively use perforin-dependent cytolysis as an effector mechanism in vitro, as well as in vivo. This review summarizes the most important role of perforin-dependent cytolysis in a wide variety of bacterial and viral infections, in tumour surveillance, in immunopathology and in autoimmunity.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://fredi.hepvs.ch/global/documents/3921
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