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Iridium-catalyzed asymmetric hydrogenation of unfunctionalized enamines.
Journal article

Iridium-catalyzed asymmetric hydrogenation of unfunctionalized enamines.

  • Baeza A Department of Chemistry, University of Basel, St. Johanns Ring 19, 4056 Basel, Switzerland.
  • Pfaltz A
  • 2009-01-30
Published in:
  • Chemistry (Weinheim an der Bergstrasse, Germany). - 2009
Amines
Catalysis
Hydrogenation
Iridium
Molecular Structure
English Optically active tertiary amines are readily prepared by iridium-catalyzed asymmetric hydrogenation of unfunctionalized enamines (see scheme). The best enantioselectivities with >90% ee were obtained with N-aryl- and N-benzyl-substituted enamines with a terminal double bond. The hydrogenation of enamines derived from cyclic ketones, which has not been reported yet with other catalysts, gave enantiomeric excesses of up to 87%.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://fredi.hepvs.ch/global/documents/37261
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