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Immunohistological evaluation of endothelial markers and basement membrane components in port-wine stains.
Journal article

Immunohistological evaluation of endothelial markers and basement membrane components in port-wine stains.

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  • 1988-01-01
Published in:
  • Dermatologica. - 1988
Adolescent
Adult
Basement Membrane
Child
Endothelium
Fluorescent Antibody Technique
Hemangioma
Humans
Immunoenzyme Techniques
Middle Aged
Skin Neoplasms
Telangiectasis
English As shown by an immunohistological study, the endothelial cells in the lesions of port-wine stains (PWSs), investigated for factor VIII-related antigen and Ulex europaeus agglutinin I lectin, were found to be swollen or flattened corresponding to mild or pronounced dilatation of vessels, respectively. Furthermore, dilated vessels in the lesional skin exhibited a broader staining for type IV collagen, laminin and fibronectin, which, however, was not considered to be of primary pathogenetic importance for vessel dilatation in PWSs. As concluded from the number of vessels, no vascular proliferation occurred, which indicates that PWS is not a true hemangioma but a special clinical type of telangiectasia.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://fredi.hepvs.ch/global/documents/3053
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