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Retinal Features in Cynomolgus Macaques (Macaca fascicularis) Assessed by Using Scanning Laser Ophthalmoscopy and Spectral Domain Optical Coherence Tomography.
Journal article

Retinal Features in Cynomolgus Macaques (Macaca fascicularis) Assessed by Using Scanning Laser Ophthalmoscopy and Spectral Domain Optical Coherence Tomography.

  • Denk N Pharma Research and Early Development (pRED), Pharmaceutical Sciences (PS), Roche Innovation Center Basel, Basel, Switzerland;, Email: nora.denk@roche.com.
  • Maloca PM Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland; Moorfields Eye Hospital, London, United Kingdom; OCTlab Research Laboratory, Department of Ophthalmology, University of Basel, Basel, Switzerland.
  • Steiner G Pharma Research and Early Development (pRED), Pharmaceutical Sciences (PS), Roche Innovation Center Basel, Basel, Switzerland.
  • Booler H Genentech, South San Francisco, California.
  • Freichel C Pharma Research and Early Development (pRED), Pharmaceutical Sciences (PS), Roche Innovation Center Basel, Basel, Switzerland.
  • Niklaus S Pharma Research and Early Development (pRED), Pharmaceutical Sciences (PS), Roche Innovation Center Basel, Basel, Switzerland.
  • Schnitzer TK Pharma Research and Early Development (pRED), Pharmaceutical Sciences (PS), Roche Innovation Center Basel, Basel, Switzerland.
  • Hasler PW OCTlab Research Laboratory, Department of Ophthalmology, University of Basel, Basel, Switzerland.
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  • 2020-03-14
Published in:
  • Comparative medicine. - 2020
General Biochemistry, Genetics and Molecular Biology
General Veterinary
English Cynomolgus macaques are an important and commonly used species in preclinical toxicology studies, but structural reports of in vivo retinal findings are rare in this species. The purpose of this study was to diminish this gap and document optical coherence tomography and scanning laser ophthalmoscopy imaging data in the healthy posterior pole of cynomolgus monkeys' eyes at predose examinations. The current study is a retrospective assessment of baseline spectral domain OCT data obtained from the 768 eyes of 384 cynomolgus monkeys (192 males and 192 females) of Mauritian origin. The data set was obtained from studies conducted over a 4-y period in the context of ocular safety evaluations of various compounds under preclinical development. The most prevalent findings were the presence of Bergmeister papilla and intravitreal hyperreflective spots. Less common findings included disorganization of retinal zones, abnormalities of the retinal vasculature, partial posterior vitreous detachment, and abnormally shaped foveal pits. Thoughtful consideration of these physiologic findings will aid in distinguishing normal features from toxic outcomes in future preclinical ophthalmic studies.
Language
  • English
Open access status
green
Identifiers
Persistent URL
https://fredi.hepvs.ch/global/documents/290176
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