Journal article
Catalytic, enantioselective, conjugate alkyne addition.
- Knöpfel TF Laboratorium für Organische Chemie, ETH Hönggerberg, CH-8093 Zürich, Switzerland.
- Zarotti P
- Ichikawa T
- Carreira EM
- 2005-07-07
Published in:
- Journal of the American Chemical Society. - 2005
English
We document a copper-catalyzed, enantioselective, conjugate addition involving the direct use of a terminal acetylene, which undergoes in situ metalation. The addition reactions of phenylacetylene to Meldrum's acid derived acceptors take place in aqueous media, without recourse to inert atmosphere. The success of the enantioselective process was enabled by the use of a new class of conveniently accessed P,N-ligands, which we have termed PINAP. These modular ligands are responsive to numerous electronic and steric modifications that permit optimization of the reaction.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1021/ja052411r
- PMID 15998061
- Persistent URL
- https://fredi.hepvs.ch/global/documents/222798
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