Journal article
Transsynaptic Retrograde Degeneration: Clinical Evidence with Homonymous RGCL Loss on OCT.
- Meier P Neuro-Ophthalmology Unit, Hôpital Ophtalmique Jules-Gonin, University of Lausanne, Switzerland.
- Maeder P Radiology Department CHUV, University of Lausanne, Switzerland.
- Borruat FX Neuro-Ophthalmology Unit, Hôpital Ophtalmique Jules-Gonin, University of Lausanne, Switzerland.
- 2016-04-27
Published in:
- Klinische Monatsblatter fur Augenheilkunde. - 2016
Adult
Aged
Diagnosis, Differential
Evidence-Based Medicine
Female
Humans
Male
Middle Aged
Reproducibility of Results
Retina
Retinal Degeneration
Retinal Ganglion Cells
Retrograde Degeneration
Sensitivity and Specificity
Tomography, Optical Coherence
Visual Pathways
English
BACKGROUND
Retinal thinning after a retrogeniculate lesion (transsynaptic retrograde degeneration) was first described 50 years ago, but has long been a controversial issue. It is now possible to use OCT for the in vivo measurement of retinal thickness.
MATERIAL AND METHODS
This was a retrospective study of patients with homonymous visual field loss, with SD-OCT assessment (RNFL and RGCL measurements) in isolated retrogeniculate lesions, subsequently confirmed by a neuroradiologist.
RESULTS
Nine patients with vascular, inflammatory or tumour brain lesions were included in the study. Homonymous RGCL thinning was found in all patients, and correlated with the visual field defect. No correlation was found with RNFL.
CONCLUSIONS
The homonymous defect of RGCL in patients with retrogeniculate lesions demonstrates the presence of transsynaptic retrograde degeneration. RGCL is a better predictor of visual field defects than RNFL measurement.
Retinal thinning after a retrogeniculate lesion (transsynaptic retrograde degeneration) was first described 50 years ago, but has long been a controversial issue. It is now possible to use OCT for the in vivo measurement of retinal thickness.
MATERIAL AND METHODS
This was a retrospective study of patients with homonymous visual field loss, with SD-OCT assessment (RNFL and RGCL measurements) in isolated retrogeniculate lesions, subsequently confirmed by a neuroradiologist.
RESULTS
Nine patients with vascular, inflammatory or tumour brain lesions were included in the study. Homonymous RGCL thinning was found in all patients, and correlated with the visual field defect. No correlation was found with RNFL.
CONCLUSIONS
The homonymous defect of RGCL in patients with retrogeniculate lesions demonstrates the presence of transsynaptic retrograde degeneration. RGCL is a better predictor of visual field defects than RNFL measurement.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1055/s-0041-111535
- PMID 27116491
- Persistent URL
- https://fredi.hepvs.ch/global/documents/19331
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