Dysfunctional insular connectivity during reward prediction in patients with first-episode psychosis.
- Schmidt A From the Department of Psychiatry (UPK), University of Basel, Switzerland (Schmidt, Smieskova, Simon, Rössler, Lang, Borgwardt); the Institute of Psychiatry, Department of Psychosis Studies, King's College London, UK (Schmidt, Fusar-Poli, McGuire, Borgwardt); the Medical Image Analysis Center (MIAC), University Hospital Basel, Switzerland (Schmidt, Smieskova, Borgwardt); the Departments of Psychiatry and Medical Biophysics, Western Univeristy, London, Ont., Canada (Palaniyappan); and the Division of Psychiatry, University of Nottingham, UK (Palaniyappan).
- Palaniyappan L From the Department of Psychiatry (UPK), University of Basel, Switzerland (Schmidt, Smieskova, Simon, Rössler, Lang, Borgwardt); the Institute of Psychiatry, Department of Psychosis Studies, King's College London, UK (Schmidt, Fusar-Poli, McGuire, Borgwardt); the Medical Image Analysis Center (MIAC), University Hospital Basel, Switzerland (Schmidt, Smieskova, Borgwardt); the Departments of Psychiatry and Medical Biophysics, Western Univeristy, London, Ont., Canada (Palaniyappan); and the Division of Psychiatry, University of Nottingham, UK (Palaniyappan).
- Smieskova R From the Department of Psychiatry (UPK), University of Basel, Switzerland (Schmidt, Smieskova, Simon, Rössler, Lang, Borgwardt); the Institute of Psychiatry, Department of Psychosis Studies, King's College London, UK (Schmidt, Fusar-Poli, McGuire, Borgwardt); the Medical Image Analysis Center (MIAC), University Hospital Basel, Switzerland (Schmidt, Smieskova, Borgwardt); the Departments of Psychiatry and Medical Biophysics, Western Univeristy, London, Ont., Canada (Palaniyappan); and the Division of Psychiatry, University of Nottingham, UK (Palaniyappan).
- Simon A From the Department of Psychiatry (UPK), University of Basel, Switzerland (Schmidt, Smieskova, Simon, Rössler, Lang, Borgwardt); the Institute of Psychiatry, Department of Psychosis Studies, King's College London, UK (Schmidt, Fusar-Poli, McGuire, Borgwardt); the Medical Image Analysis Center (MIAC), University Hospital Basel, Switzerland (Schmidt, Smieskova, Borgwardt); the Departments of Psychiatry and Medical Biophysics, Western Univeristy, London, Ont., Canada (Palaniyappan); and the Division of Psychiatry, University of Nottingham, UK (Palaniyappan).
- Riecher-Rössler A From the Department of Psychiatry (UPK), University of Basel, Switzerland (Schmidt, Smieskova, Simon, Rössler, Lang, Borgwardt); the Institute of Psychiatry, Department of Psychosis Studies, King's College London, UK (Schmidt, Fusar-Poli, McGuire, Borgwardt); the Medical Image Analysis Center (MIAC), University Hospital Basel, Switzerland (Schmidt, Smieskova, Borgwardt); the Departments of Psychiatry and Medical Biophysics, Western Univeristy, London, Ont., Canada (Palaniyappan); and the Division of Psychiatry, University of Nottingham, UK (Palaniyappan).
- Lang UE From the Department of Psychiatry (UPK), University of Basel, Switzerland (Schmidt, Smieskova, Simon, Rössler, Lang, Borgwardt); the Institute of Psychiatry, Department of Psychosis Studies, King's College London, UK (Schmidt, Fusar-Poli, McGuire, Borgwardt); the Medical Image Analysis Center (MIAC), University Hospital Basel, Switzerland (Schmidt, Smieskova, Borgwardt); the Departments of Psychiatry and Medical Biophysics, Western Univeristy, London, Ont., Canada (Palaniyappan); and the Division of Psychiatry, University of Nottingham, UK (Palaniyappan).
- Fusar-Poli P From the Department of Psychiatry (UPK), University of Basel, Switzerland (Schmidt, Smieskova, Simon, Rössler, Lang, Borgwardt); the Institute of Psychiatry, Department of Psychosis Studies, King's College London, UK (Schmidt, Fusar-Poli, McGuire, Borgwardt); the Medical Image Analysis Center (MIAC), University Hospital Basel, Switzerland (Schmidt, Smieskova, Borgwardt); the Departments of Psychiatry and Medical Biophysics, Western Univeristy, London, Ont., Canada (Palaniyappan); and the Division of Psychiatry, University of Nottingham, UK (Palaniyappan).
- McGuire P From the Department of Psychiatry (UPK), University of Basel, Switzerland (Schmidt, Smieskova, Simon, Rössler, Lang, Borgwardt); the Institute of Psychiatry, Department of Psychosis Studies, King's College London, UK (Schmidt, Fusar-Poli, McGuire, Borgwardt); the Medical Image Analysis Center (MIAC), University Hospital Basel, Switzerland (Schmidt, Smieskova, Borgwardt); the Departments of Psychiatry and Medical Biophysics, Western Univeristy, London, Ont., Canada (Palaniyappan); and the Division of Psychiatry, University of Nottingham, UK (Palaniyappan).
- Borgwardt SJ From the Department of Psychiatry (UPK), University of Basel, Switzerland (Schmidt, Smieskova, Simon, Rössler, Lang, Borgwardt); the Institute of Psychiatry, Department of Psychosis Studies, King's College London, UK (Schmidt, Fusar-Poli, McGuire, Borgwardt); the Medical Image Analysis Center (MIAC), University Hospital Basel, Switzerland (Schmidt, Smieskova, Borgwardt); the Departments of Psychiatry and Medical Biophysics, Western Univeristy, London, Ont., Canada (Palaniyappan); and the Division of Psychiatry, University of Nottingham, UK (Palaniyappan).
- 2016-02-09
Published in:
- Journal of psychiatry & neuroscience : JPN. - 2016
Adult
Anticipation, Psychological
Antipsychotic Agents
Bayes Theorem
Brain Mapping
Cerebral Cortex
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Models, Neurological
Neural Pathways
Neuropsychological Tests
Psychiatric Status Rating Scales
Psychotic Disorders
Reward
Young Adult
English
BACKGROUND
Increasing evidence indicates that psychosis is associated with abnormal reward processing. Imaging studies in patients with first-episode psychosis (FEP) have revealed reduced activity in diverse brain regions, including the ventral striatum, insula and anterior cingulate cortex (ACC), during reward prediction. However, whether these reductions in local brain activity are due to altered connectivity has rarely been explored.
METHODS
We applied dynamic causal modelling and Bayesian model selection to fMRI data during the Salience Attribution Task to investigate whether patients with FEP showed abnormal modulation of connectivity between the ventral striatum, insula and ACC induced by rewarding cues and whether these changes were related to positive psychotic symptoms and atypical antipsychotic medication.
RESULTS
The model including reward-induced modulation of insula-ACC connectivity was the best fitting model in each group. Compared with healthy controls (n = 19), patients with FEP (n = 29) revealed reduced right insula-ACC connectivity. After subdividing patients according to current antipsychotic medication, we found that the reduced insula-ACC connectivity relative to healthy controls was observed only in untreated patients (n = 17), not in patients treated with antipsychotics (n = 12), and that it correlated negatively with unusual thought content in untreated patients with FEP.
LIMITATIONS
The modest sample size of untreated patients with FEP was a limitation of our study.
CONCLUSION
This study indicates that insula-ACC connectivity during reward prediction is reduced in untreated patients with FEP and related to the formation of positive psychotic symptoms. Our study further suggests that atypical antipsychotics may reverse connectivity between the insula and the ACC during reward prediction.
Increasing evidence indicates that psychosis is associated with abnormal reward processing. Imaging studies in patients with first-episode psychosis (FEP) have revealed reduced activity in diverse brain regions, including the ventral striatum, insula and anterior cingulate cortex (ACC), during reward prediction. However, whether these reductions in local brain activity are due to altered connectivity has rarely been explored.
METHODS
We applied dynamic causal modelling and Bayesian model selection to fMRI data during the Salience Attribution Task to investigate whether patients with FEP showed abnormal modulation of connectivity between the ventral striatum, insula and ACC induced by rewarding cues and whether these changes were related to positive psychotic symptoms and atypical antipsychotic medication.
RESULTS
The model including reward-induced modulation of insula-ACC connectivity was the best fitting model in each group. Compared with healthy controls (n = 19), patients with FEP (n = 29) revealed reduced right insula-ACC connectivity. After subdividing patients according to current antipsychotic medication, we found that the reduced insula-ACC connectivity relative to healthy controls was observed only in untreated patients (n = 17), not in patients treated with antipsychotics (n = 12), and that it correlated negatively with unusual thought content in untreated patients with FEP.
LIMITATIONS
The modest sample size of untreated patients with FEP was a limitation of our study.
CONCLUSION
This study indicates that insula-ACC connectivity during reward prediction is reduced in untreated patients with FEP and related to the formation of positive psychotic symptoms. Our study further suggests that atypical antipsychotics may reverse connectivity between the insula and the ACC during reward prediction.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1503/jpn.150234
- PMID 26854756
- Persistent URL
- https://fredi.hepvs.ch/global/documents/160370
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