Bacterial beta-peptidyl aminopeptidases: on the hydrolytic degradation of beta-peptides.
- 2007-02-24
Published in:
- Applied microbiology and biotechnology. - 2007
English
The special chemical and biological features of beta-peptides have been investigated intensively during recent years. Many studies emphasize the restricted biodegradability and the high metabolic stability of this class of compounds. beta-Peptidyl aminopeptidases form the first family of enzymes that hydrolyze a variety of short beta-peptides and beta-amino-acid-containing peptides. All representatives of this family were isolated from Gram-negative bacteria. The substrate specificities of the peptidases vary greatly, but the enzymes have common structural properties, and a similar reaction mechanism can be expected. This review gives an overview on the beta-peptidyl aminopeptidases with emphasis on their biochemical and structural properties. Their possible physiological function is discussed. Functionally and structurally related enzymes are compared to the beta-peptidyl aminopeptidases.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1007/s00253-007-0872-5
- PMID 17318535
- Persistent URL
- https://fredi.hepvs.ch/global/documents/156408
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