Back
Natural and synthetic selenoproteins.
Journal article

Natural and synthetic selenoproteins.

  • Metanis N Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. Electronic address: metanis@mail.huji.ac.il.
  • Hilvert D Laboratory of Organic Chemistry, ETH Zürich, 8093 Zürich, Switzerland. Electronic address: hilvert@org.chem.ethz.ch.
  • 2014-09-29
Published in:
  • Current opinion in chemical biology. - 2014
Animals
Humans
Oxidation-Reduction
Protein Biosynthesis
Protein Folding
Recombinant Proteins
Selenocysteine
Selenoproteins
English Once considered highly toxic, the element selenium is now recognized as a micronutrient essential for human health. It is inserted co-translationally into many proteins as the non-canonical amino acid selenocysteine, providing the resulting selenoprotein molecules with a range of valuable redox properties; selenocysteine is also increasingly exploited as a structural and mechanistic probe in synthetic peptides and proteins. Here we review topical investigations into the preparation and characterization of natural and artificial selenoproteins. Such molecules are uniquely suited as tools for protein chemistry and as a test bed for studying novel catalytic activities.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://fredi.hepvs.ch/global/documents/153442
Statistics
Document views: 39 File downloads: