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5-(Pyrrolidin-2-yl)tetrazole-catalyzed aldol and mannich reactions: acceleration and lower catalyst loading in a continuous-flow reactor.
Journal article

5-(Pyrrolidin-2-yl)tetrazole-catalyzed aldol and mannich reactions: acceleration and lower catalyst loading in a continuous-flow reactor.

  • Odedra A Laboratory for Organic Chemistry, Swiss Federal Institute of Technology (ETH) Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland.
  • Seeberger PH
  • 2009-03-17
Published in:
  • Angewandte Chemie (International ed. in English). - 2009
Aldehydes
Catalysis
Ketones
Proline
Pyrrolidines
Stereoisomerism
Temperature
Tetrazoles
Time Factors
English Continuous organocatalysis: Fast aldol and Mannich reactions require less catalyst when conducted in a microreactor. A proline tetrazole derivative (5-10 mol %) catalyzes asymmetric aldol reactions between various aromatic aldehydes and ketones in microreactor at 60 degrees C with reaction times ranging from 10 to 30 min.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://fredi.hepvs.ch/global/documents/142770
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